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Polypeptide-Conjugated Second Near-Infrared Organic Fluorophore for Image-Guided Photothermal Therapy.
ACS Nano ( IF 15.8 ) Pub Date : 2019-02-21 00:00:00 , DOI: 10.1021/acsnano.9b00452
Tuanwei Li 1 , Chunyan Li 2 , Zheng Ruan 1 , Pengping Xu 3 , Xiaohu Yang 2 , Pan Yuan 1 , Qiangbin Wang 2, 4 , Lifeng Yan 1
ACS Nano ( IF 15.8 ) Pub Date : 2019-02-21 00:00:00 , DOI: 10.1021/acsnano.9b00452
Tuanwei Li 1 , Chunyan Li 2 , Zheng Ruan 1 , Pengping Xu 3 , Xiaohu Yang 2 , Pan Yuan 1 , Qiangbin Wang 2, 4 , Lifeng Yan 1
Affiliation
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Image-guided photothermal therapy (PTT) is an attractive strategy to improve the diagnosis accuracy and treatment outcomes by monitoring the accumulation of photothermal agents in tumors in real-time and determining the best treatment window. Taking advantage of the superior imaging quality of NIR-II fluorescence imaging and remote-controllable phototherapy modality of PTT, we developed a facile macromolecular fluorophore (PF) by conjugating a small-molecule NIR-II fluorophore (Flav7) with an amphiphilic polypeptide. The PF can form uniform micelles in aqueous solution, which exhibit a slight negative charge. In vitro experimental results showed that the PF nanoparticles showed satisfactory photophysical properties, prominent photothermal conversion efficiency (42.3%), excellent photothermal stability, negligible cytotoxicity, and photothermal toxicity. Meanwhile, the PF can visualize and feature the tumors by NIR-II fluorescence imaging owing to prolonged blood circulation time and enhanced accumulation in tumors. Moreover, in vivo studies revealed that the PF nanoparticles achieved an excellent photothermal ablation effect on tumors with a low dose of NIR-II dye and light irradiation, and the process can be traced by NIR fluorescence imaging.
中文翻译:
多肽偶联的第二种近红外有机荧光团,用于图像引导的光热疗法。
图像引导光热疗法(PTT)是一种有吸引力的策略,可通过实时监测肿瘤中光热剂的积累并确定最佳治疗窗口来提高诊断准确性和治疗结果。利用NIR-II荧光成像的卓越成像质量和PTT的远程可控光疗模式,我们通过将小分子NIR-II荧光基团(Flav7)与两亲性多肽结合,开发了一种简便的大分子荧光基团(PF)。PF可以在水溶液中形成均匀的胶束,并显示出轻微的负电荷。体外实验结果表明,PF纳米颗粒具有令人满意的光物理性质,显着的光热转化效率(42.3%),优异的光热稳定性,可忽略的细胞毒性和光热毒性。同时,由于延长了血液循环时间和增加了肿瘤的蓄积,PF可以通过NIR-II荧光成像来可视化和表征肿瘤。此外,体内研究表明,PF纳米颗粒以低剂量的NIR-II染料和光照射对肿瘤实现了优异的光热消融效果,并且该过程可以通过NIR荧光成像来追踪。
更新日期:2019-02-21
中文翻译:
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多肽偶联的第二种近红外有机荧光团,用于图像引导的光热疗法。
图像引导光热疗法(PTT)是一种有吸引力的策略,可通过实时监测肿瘤中光热剂的积累并确定最佳治疗窗口来提高诊断准确性和治疗结果。利用NIR-II荧光成像的卓越成像质量和PTT的远程可控光疗模式,我们通过将小分子NIR-II荧光基团(Flav7)与两亲性多肽结合,开发了一种简便的大分子荧光基团(PF)。PF可以在水溶液中形成均匀的胶束,并显示出轻微的负电荷。体外实验结果表明,PF纳米颗粒具有令人满意的光物理性质,显着的光热转化效率(42.3%),优异的光热稳定性,可忽略的细胞毒性和光热毒性。同时,由于延长了血液循环时间和增加了肿瘤的蓄积,PF可以通过NIR-II荧光成像来可视化和表征肿瘤。此外,体内研究表明,PF纳米颗粒以低剂量的NIR-II染料和光照射对肿瘤实现了优异的光热消融效果,并且该过程可以通过NIR荧光成像来追踪。