Revolutionizing immunology with single-cell RNA sequencing.,Cellular & Molecular Immunology

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Revolutionizing immunology with single-cell RNA sequencing.
Cellular & Molecular Immunology ( IF 21.8 ) Pub Date : 2019-02-22 , DOI: 10.1038/s41423-019-0214-4
Haide Chen _{1,

2,

3} , Fang Ye ₁ , Guoji Guo _{1,

2,

3,

4,

5}

Affiliation

The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Identifying heterogeneity of immune cells is the key to understanding the immune system. Advanced single-cell RNA sequencing (scRNA-seq) technologies are revolutionizing our ability to study immunology. By measuring transcriptomes at the single-cell level, scRNA-seq enables identification of cellular heterogeneity in far greater detail than conventional methods. In this review, we introduce the existing scRNA-seq technologies and present their strengths and weaknesses. We also discuss potential applications and future innovations of scRNA-seq in immunology.

中文翻译：

用单细胞RNA测序彻底改变免疫学。

免疫系统由复杂的细胞类型层次组成，可以保护生物体免受疾病侵害并保持体内平衡。识别免疫细胞的异质性是了解免疫系统的关键。先进的单细胞RNA测序（scRNA-seq）技术正在彻底改变我们研究免疫学的能力。通过在单细胞水平上测量转录组，scRNA-seq可以比传统方法更详细地鉴定细胞异质性。在本文中，我们介绍了现有的scRNA-seq技术，并介绍了它们的优缺点。我们还将讨论scRNA-seq在免疫学中的潜在应用和未来的创新。

更新日期：2019-07-05

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