Copper‐Catalyzed Annulation/A3‐Coupling Cascade: Diastereodivergent Synthesis of Sterically Hindered Monocyclic Oxazolidines Bearing Multiple Stereocenters,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper‐Catalyzed Annulation/A3‐Coupling Cascade: Diastereodivergent Synthesis of Sterically Hindered Monocyclic Oxazolidines Bearing Multiple Stereocenters
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2019-02-22 , DOI: 10.1002/ejoc.201900031
Huangdi Feng ₁ , Yazhen Zhang ₁ , Zedi Zhang ₁ , Fubei Chen ₁ , Liliang Huang ₁

Affiliation

An efficient strategy for the synthesis of sterically hindered chiral N‐propargyl oxazolidines bearing multiple stereocenters through copper‐catalyzed domino A³ reaction has been successfully disclosed. The chiral plenylglycinol precursor allowed the attainment of the target products in good yields (up to 90 %) with excellent diastereomeric ratio (> 20:1). Facile operation in open‐air, solvent‐free, and one‐pot process makes this method practical and attractive.

中文翻译：

铜催化的环形/ A3耦合级联：带有多个立体中心的立体受阻单环恶唑烷的非对映发合成

已经成功地公开了通过铜催化的多米诺骨牌A ³反应合成具有多个立体中心的空间位阻性手性N-炔丙基恶唑烷的有效策略。手性烯基甘氨醇前体允许以优异的非对映体比率（> 20：1）以良好的收率（最高90％）获得目标产物。露天，无溶剂和一锅法的简便操作使该方法实用且有吸引力。

更新日期：2019-02-22

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南