Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full‐thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid‐graft‐dopamine and reduced graphene oxide (rGO) using a H₂O₂/HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self‐healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full‐thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full‐thickness skin repair.

中文翻译：

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具有持续释放药物和光热抗菌活性，可促进伤口愈合过程中全层皮肤再生的粘性止血可注射复合水凝胶。

在临床应用中，非常需要开发具有多种功能的可注射纳米复合导电水凝胶敷料，其中包括粘合性，抗菌和自由基清除能力以及良好的机械性能，以增强全厚度皮肤伤口的再生能力。在这里，一系列透明质酸-接枝-多巴胺和使用H ₂ O ₂还原氧化石墨烯（rGO）的系列止血抗氧化剂导电光热抗菌水凝胶/ HPR（辣根过氧化物酶）系统已准备好用于伤口包扎。这些水凝胶显示出高溶胀性，可降解性，可调节的流变性质，以及与人类皮肤相似或优异的机械性质。研究了聚多巴胺赋予的抗氧化活性，组织粘附性和止血能力，自愈能力，电导率以及近红外辐射增强了水凝胶的体内抗菌性能。而且，药物释放和抑制区域测试证实了水凝胶的持续药物释放能力。此外，水凝胶敷料可通过上调CD31的生长因子表达来显着增强血管生成，并改善肉芽组织的厚度和胶原蛋白的沉积，与市售Tegaderm电影小组相比，所有这些都可以促进伤口闭合，并在小鼠全层伤口模型中提供更好的治疗效果。总而言之，这些具有持续药物释放特性，可促进皮肤完全再生的止血抗氧化导电水凝胶是用于全层皮肤修复的出色伤口敷料。