An Efficient and Facile Synthesis of tert‐Butyl 2‐(Methylamino)‐3‐nitro‐5‐oxo‐4‐aryl‐7,8‐dihydro‐4H‐pyrano[3,2‐c]pyridine‐6(5H)‐carboxylate derivatives in [BMIM]BF4,Journal of Heterocyclic Chemistry

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An Efficient and Facile Synthesis of tert‐Butyl 2‐(Methylamino)‐3‐nitro‐5‐oxo‐4‐aryl‐7,8‐dihydro‐4H‐pyrano[3,2‐c]pyridine‐6(5H)‐carboxylate derivatives in [BMIM]BF4
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2019-02-20 , DOI: 10.1002/jhet.3517
Zhengbing Pan ₁ , Hui Xu ₁ , Kaimin Mao ₁ , Lei Dai ₁ , Liming Zhao ₁ , Liangce Rong ₁

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In this research, we have developed an efficient three‐component reaction for the synthesis of pyrano[3,2‐c]pyridine derivatives from the reaction of aromatic aldehydes, tert‐butyl 2,4‐dioxopiperidine‐1‐carboxylate, and N‐methyl‐1‐(methylthio)‐2‐nitroethylen‐1‐amine in [BMIM]BF₄ medium. The advantages of this method were readily available starting materials, simple reaction conditions, and satisfactory yields.

中文翻译：

高效简便地合成叔丁基2-（甲基氨基）-3-硝基-5-氧代-4-芳基-7,8-二氢-4H-吡喃并[3,2-c]吡啶-6（5H）- [BMIM] BF4中的羧酸酯衍生物

在本研究中，我们开发了用于吡喃的合成的有效三组分反应并[3,2- c ^ ]吡啶从芳香醛的反应衍生物，叔丁基2,4-二氧代哌啶-1-羧酸叔丁酯，和Ñ - [BMIM] BF ₄培养基中的甲基-1-（甲硫基）-2-硝基亚乙基-1-胺。该方法的优点是容易获得的起始原料，简单的反应条件和令人满意的产率。

更新日期：2019-02-20

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