[Emim][BF4]: An Efficient Green Protocol for the Synthesis of Bioactive 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐dione Derivatives,Journal of Heterocyclic Chemistry

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[Emim][BF4]: An Efficient Green Protocol for the Synthesis of Bioactive 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐dione Derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2018-01-11 , DOI: 10.1002/jhet.3066
Jorepalli Sumalatha ₁ , Chinthaparthi Radha Rani _{2,

3} , Adikay Sreedevi ₁

Affiliation

The present study is designed to synthesize the 2‐(5‐(substituted)‐2,6‐dioxo‐1,2,5,6‐tetrahydropyrimidin‐4‐yl)‐2,3‐dihydrophthalazine‐1,4‐diones and investigate their anticancer activity. This is the first example of the condensation reaction of a series of phthalhydrazide derivatives in ionic liquid. In this investigation, the titled compounds syntheses were carried out by simple and efficient three component coupling of phthalhydrazide, aldehydes, and barbituric acid in the presence of [Emim][BF₄] ionic liquid. This methodology was provided and promotes the higher product yields in shorter reaction times and mild reaction conditions. The title compounds were tested for their anticancer activity. Some of them were shown the significant cytotoxic activity against the selected cancer cell lines.

中文翻译：

[Emim] [BF4]：合成生物活性2-（5-（取代）-2-，6-二氧代-1,2,5,6-四氢嘧啶-4-基）-2-，3-的高效绿色方案dihydrophthalazine-1,4-dione衍生物

本研究旨在合成2-（5-（取代的）-2-，6-二氧代-1,2,5,6-四氢嘧啶-4-基）-2-，3-二氢邻苯二甲酰-1,4-二酮和调查其抗癌活性。这是一系列邻苯二甲酰肼衍生物在离子液体中缩合反应的第一个例子。在这项研究中，标题化合物的合成是在[Emim] [BF ₄ ]离子液体存在下，通过邻苯二甲酰肼，醛和巴比妥酸的简单有效的三组分偶联来进行的。提供了这种方法，可在较短的反应时间和温和的反应条件下提高较高的产品收率。测试标题化合物的抗癌活性。他们中的一些被证明对选定的癌细胞系具有显着的细胞毒活性。

更新日期：2018-01-11

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