Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells,Molecular Pharmaceutics

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Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-02-04 00:00:00 , DOI: 10.1021/acs.molpharmaceut.7b00920
James A. Vassie ₁ , John M. Whitelock ₁ , Megan S. Lord ₁

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Cerium oxide nanoparticles (nanoceria) are promising catalytic nanomaterials that are widely reported to modulate intracellular reactive oxygen species (ROS). In this study, nanoceria were synthesized by flame spray pyrolysis and functionalized with a cell-targeting ligand, folic acid (FA). The surface functionalization of nanoceria was stable, and FA enhanced the uptake of nanoceria via folate receptors. Internalized nanoceria and FA-nanoceria were localized predominantly in the cytoplasm. FA-nanoceria modulated intracellular ROS to a greater extent than the nanoceria in colon carcinoma cells, but induced ROS in ovarian cancer cells, likely due to their enhanced uptake. Together these data demonstrated that the functionalization of nanoceria with FA modulated their endocytosis and redox activity, and they may find application in the delivery of anticancer drugs in the future.

中文翻译：

叶酸功能化纳米氧化铈在肿瘤细胞中的靶向递送和氧化还原活性

氧化铈纳米颗粒（纳米藻）是有前途的催化纳米材料，广泛报道其可调节细胞内活性氧（ROS）。在这项研究中，纳米氧化铈是通过火焰喷雾热解法合成的，并用靶向细胞的配体叶酸（FA）进行了功能化。纳米氧化铈的表面功能稳定，并且FA通过叶酸受体增强了纳米氧化铈的吸收。内在的纳米氧化铈和FA纳米细菌主要定位在细胞质中。与结肠癌细胞中的纳米氧化铈相比，FA纳米细菌对细胞内ROS的调节程度更大，但在卵巢癌细胞中却诱导了ROS，这可能是由于它们的摄取增加所致。这些数据共同证明，纳米二氧化铈与FA的功能性调节了它们的内吞作用和氧化还原活性，

更新日期：2018-02-04

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