Phenylamine has been recognized as one of the most important industrially relevant ingredient and a crucial intermediate in chemical products. Yet, its internal exposure detection in human remains largely elusive due to the lack of potent monitoring method. Hereby this issue is addressed with a probe based on lanthanide functionalized organic-inorganic hybrid material Al(OH)(bpydc) (1) through post-synthetically modified metal-organic framework. The as-synthesized Tb3+@1 exhibits the strong luminescence of Tb3+ originated from efficient energy transfer from the ligand, which can sense the biological metabolite p-aminophenol (PAP) of the phenylamine in the human urine. Linear correlation between the integrated fluorescence intensity and the concentration of PAP was investigated, enabling quantitative analysis of PAP in physiologically ranges (0.005-5 mg mL-1) with low detection limit (5 μg mL-1). This probe demonstrates excellent sensitivity, high selectivity, good reusability and quick response to PAP. Furthermore, a simple and rapid smartphone-based medical portable test paper was developed, whose quantitative color change can be easily distinguished visually. Hence, the PAP sensing platform can serve as a potential diagnostic tool for home monitoring of PAP.

中文翻译：

---

基于Tb 3+ 功能化金属有机骨架的人尿苯胺生物标志物即时比色检测

苯胺已被公认为最重要的工业相关成分之一，也是化工产品中的关键中间体。然而，由于缺乏有效的监测方法，其在人体中的内部暴露检测在很大程度上仍然难以实现。因此，该问题通过基于镧系元素官能化有机-无机杂化材料 Al(OH)(bpydc) (1) 的探针通过合成后改性的金属-有机框架得到解决。合成后的 Tb3+@1 表现出 Tb3+ 的强发光源于配体的有效能量转移，可以感知人尿中苯胺的生物代谢物对氨基苯酚 (PAP)。研究了积分荧光强度与 PAP 浓度之间的线性相关性，从而能够在生理范围内对 PAP 进行定量分析 (0. 005-5 mg mL-1)，具有低检测限 (5 μg mL-1)。该探针表现出优异的灵敏度、高选择性、良好的可重复使用性和对 PAP 的快速响应。此外，开发了一种简单快速的基于智能手机的医用便携式试纸，其定量的颜色变化可以很容易地在视觉上区分。因此，PAP 传感平台可以作为家庭监测 PAP 的潜在诊断工具。