可扩展的合成和后修饰的介孔金属有机骨架，称为NU-1000。,Nature Protocols

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可扩展的合成和后修饰的介孔金属有机骨架，称为NU-1000。
Nature Protocols ( IF 13.1 ) Pub Date : 2016-Jan-01 , DOI: 10.1038/nprot.2016.001
Timothy C Wang , Nicolaas A Vermeulen , In Soo Kim , Alex B F Martinson , J Fraser Stoddart , Joseph T Hupp , Omar K Farha

NU-1000是一种高度坚固的中孔（含孔> 2 nm）金属有机骨架（MOF）的合成，可以用便宜的起始原料在数克范围内高效进行。四溴py和（4-（乙氧基羰基）苯基）硼酸可以轻松偶联以制备必需的有机支撑物，该支撑物具有四个羧酸形式的四个金属结合位点，而八水合氧化锆用作定义明确的前体金属氧化物簇。据报道，NU-1000是气体分离的极佳候选者，它是用于多相催化的多功能支架。特别是，它是神经活性剂催化失活的理想选择，作为一种广泛应用的新型通用平台，它具有广阔的前景。已经使用NU-1000作为母体材料开发了多种合成后修饰方案，使其成为可能用于多种催化应用的支架。可以可靠地扩大NU-1000的制备程序，它适用于生产50 g含四羧酸的有机连接基和200 mg-2.5 g NU-1000。整个合成无需通过柱色谱法纯化即可进行，并且可以在10天内完成。

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Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000.

The synthesis of NU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl)phenyl)boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.

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