基于金纳米棒的色度比色传感器阵列：一个有前途的平台，用于化学识别应用,ACS Omega

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基于金纳米棒的色度比色传感器阵列：一个有前途的平台，用于化学识别应用
ACS Omega ( IF 3.7 ) Pub Date : 2018-02-01 00:00:00 , DOI: 10.1021/acsomega.7b01780
Nafiseh Fahimi-Kashani ₁ , M. Reza Hormozi-Nezhad ₁

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迄今为止，大多数基于阵列的传感平台都利用静态响应模式来区分各种分析物，但只有少数研究集中在定量解析结构异构体这一重要任务上，由于其在分子生物学中的广泛应用，如今这一点非常重要。医药和工业。实现这一壮举的一种可能方法是结合动力学（而不是静态）传感器响应曲线和化学舌策略，以允许开发基于阵列的传感器以识别异构体。在这里，通过增加时间维度，提出了一种简单新颖的基于金纳米棒（AuNR）的计时比色传感器阵列，用于化学鉴别应用。由于它们的结构相似但氧化还原电位不同，因此已选择二羟基苯（DHB）结构异构体作为模型，以评估所提出的阵列的适用性。由于DHBs的动力学行为不同，阵列的原理依赖于在不同银离子/ AuNR浓度比下AuNRs上银壳的不同生长速率，DHBs的动力学行为不同，可以借助多变量分析方法将其用作鉴定DHBs的指纹。通过线性判别分析和层次聚类分析，分析了添加DHB时AuNRs的组合色度响应。最后，鉴定真实样品中的单个DHBs或它们的混合物证实了所提出的阵列的潜在应用。

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Gold Nanorod-Based Chrono-Colorimetric Sensor Arrays: A Promising Platform for Chemical Discrimination Applications

Most array-based sensing platforms, to date, utilize static response patterns for discrimination of a wide variety of analytes, but only a few studies have focused on the important task of quantitatively resolving structural isomers, which are nowadays important because of their broad usage in medicines and industries. A possible way of accomplishing this feat is to combine kinetic (rather than static) sensor response profiles with the chemical tongue strategy to allow the development of array-based sensors for isomeric discrimination. Here, by adding the time dimension, a simple and novel gold nanorod (AuNR)-based chrono-colorimetric sensor array is proposed for chemical discrimination applications. Because of their similar structure but different redox potentials, dihydroxybenzene (DHB) structural isomers have been chosen, as models, to evaluate the applicability of the proposed array. The principle of the array relies on various growth rates of silver shells on AuNRs at different silver ion/AuNR concentration ratios owing to the different kinetic behaviors of DHBs, which can be used as fingerprints to identify DHBs with the help of multivariate analysis methods. The combinatorial colorimetric response of AuNRs upon DHB addition has been analyzed by linear discriminant analysis and hierarchical cluster analysis. Finally, identification of individual DHBs or their mixtures in real samples confirms the potential application of the proposed array.

更新日期：2018-02-01

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