Intermediates generated in several metabolic processes are used to regulate transcription through covalent histone and DNA modifications. In Cell Reports, Das et al. show that acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury.

中文翻译：

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ATP 柠檬酸裂解酶：连接骨骼肌代谢和表观遗传学的新参与者

在几个代谢过程中产生的中间体用于通过共价组蛋白和 DNA 修饰来调节转录。在细胞报告中，Das 等人。显示由 ATP 柠檬酸裂解酶 (ACL) 产生的乙酰辅酶 A (乙酰辅酶 A) 用于在 MyoD 调节区域乙酰化组蛋白 H3，导致 MyoD 表达增加并改善受伤后的肌肉再生。