Assembling Two‐Phase Enzymatic Cascade Pathways in Pickering Emulsion,ChemCatChem

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Assembling Two‐Phase Enzymatic Cascade Pathways in Pickering Emulsion
ChemCatChem ( IF 3.8 ) Pub Date : 2019-03-13 , DOI: 10.1002/cctc.201900098
Yongchun Pan ₁ , Wu Qiu ₁ , Qin Li ₁ , Shuihong Zhu ₁ , Changxu Lin ₁ , Wenbin Zeng ₁ , Xueqing Xiong ₁ , Xiang Yang Liu _{1,

2} , Youhui Lin ₁

Affiliation

The design of enzymatic cascade pathways in biphasic systems with high efficiency is still a big challenge. Herein, we report a simple and efficient strategy for one‐pot biphasic tandem reactions by positioning distinct biocatalysts in spatially separate domains of Pickering emulsion. Due to the large interfacial area and the stability of Pickering interfacial biocatalysts, the as‐obtained Pickering emulsion system was confirmed as a nice microreactor with highly enhanced catalytic performance. Furthermore, in this hybrid catalytic system, unconventional computing relied on enzymatic cascade reactions can be performed. Such Pickering emulsion‐based logic system offers several distinctive advantages, including less “cross‐talk” and signal amplification. We believe that our result will have critical applications in future biocatalysis, nanomachines, smart diagnostics, intelligent drug delivery, nanomechanical, and electronics.

中文翻译：

在Pickering乳液中组装两相酶联级联途径

高效率的双相系统中酶促级联途径的设计仍然是一个很大的挑战。本文中，我们通过在Pickering乳剂的空间上分开的区域中放置不同的生物催化剂，报告了一种简单有效的单相双相串联反应策略。由于较大的界面面积和Pickering界面生物催化剂的稳定性，所获得的Pickering乳液体系被证实是一种很好的微反应器，具有高度增强的催化性能。此外，在该混合催化系统中，可以进行依赖于酶促级联反应的非常规计算。这种基于Pickering乳液的逻辑系统具有许多独特的优势，包括较少的“串扰”和信号放大。我们相信我们的结果将在未来的生物催化，纳米机器，

更新日期：2019-03-13

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