AbstractTwo dimensional single-crystal hexagonal gold nanosheets (SCHGNSs) were prepared by microwave heating of a solution of HAuCl4 in an ionic liquid. The SCHGNSs were characterized by field emission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, atomic force microscopy and electrochemical impedance spectroscopy. The SCHGNSs were then used to modify a graphite paste electrode for voltammetric determination of the hypertension drug captopril (CAP). The modified electrode showed a well-defined oxidation peak (at 0.41 V vs. Ag/AgCl) at pH 7.0 using differential pulse voltammetry. Under the optimum conditions, the response is linear in the 2–400 nM and 4.0–50 μM CAP concentration range, and the detection limit (at S/N = 3) is 0.3 nM. The sensor was successfully applied to the determination of CAP in pharmaceutical tablets and in spiked urine. Graphical abstractSchematic presentation of the preparation of single crystal hexagonal gold nanosheets and their use to modify a carbon paste electrode for ultra-trace voltammetric determination of the drug captopril

中文翻译：

---

用于超痕量伏安法测定卡托普利的二维单晶六方金纳米片

摘要 通过微波加热 HAuCl4 在离子液体中的溶液制备二维单晶六方金纳米片 (SCHGNSs)。通过场发射电子显微镜、能量色散 X 射线光谱、X 射线衍射、原子力显微镜和电化学阻抗谱对 SCHGNS 进行表征。然后使用 SCHGNS 修饰石墨糊电极，用于伏安法测定高血压药物卡托普利 (CAP)。使用差分脉冲伏安法，改性电极在 pH 7.0 时显示出明确的氧化峰（0.41 V vs. Ag/AgCl）。在最佳条件下，响应在 2–400 nM 和 4.0–50 μM C​​AP 浓度范围内呈线性，检测限（S/N = 3）为 0.3 nM。该传感器已成功应用于药片和加标尿液中CAP的测定。图解摘要单晶六方金纳米片的制备及其修饰碳糊电极的示意图，用于药物卡托普利的超痕量伏安测定