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Carbon Dots for In Vivo Bioimaging and Theranostics.
Small ( IF 13.0 ) Pub Date : 2019-02-18 , DOI: 10.1002/smll.201805087
Jianjun Du 1, 2 , Ning Xu 1 , Jiangli Fan 1, 2 , Wen Sun 1, 2 , Xiaojun Peng 1, 2
Affiliation  

Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, the challenges and prospects of the next‐generation of CD‐based theranostics for clinical applications are also discussed.

中文翻译:

体内生物成像和治疗学的碳点。

碳点(CD)是一种偶然发现的碳材料,在荧光成像/传感方面显示出出乎意料的优势,例如光稳定性,生物相容性和低毒性。对于新兴的治疗学,通过整合治疗和诊断方法创建的一个跨学科,CD与目标化学/基因/光动力/光热治疗部分结合时,是很好的候选者。在这里,从CD在纳米医学中的发展历程,从它们作为原始成像剂和/或药物载体到多功能治疗学系统的用途进行了回顾。最后,还讨论了用于临床应用的下一代基于CD的治疗方法学的挑战和前景。
更新日期:2019-02-18
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