Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala.,Cell

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Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala.
Cell ( IF 45.5 ) Pub Date : 2019-02-14 , DOI: 10.1016/j.cell.2019.01.024
Patrick B Chen ₁ , Rongfeng K Hu ₁ , Ye Emily Wu ₁ , Lin Pan ₁ , Shan Huang ₁ , Paul E Micevych ₂ , Weizhe Hong ₁

Affiliation

Social behaviors, including behaviors directed toward young offspring, exhibit striking sex differences. Understanding how these sexually dimorphic behaviors are regulated at the level of circuits and transcriptomes will provide insights into neural mechanisms of sex-specific behaviors. Here, we uncover a sexually dimorphic role of the medial amygdala (MeA) in governing parental and infanticidal behaviors. Contrary to traditional views, activation of GABAergic neurons in the MeA promotes parental behavior in females, while activation of this population in males differentially promotes parental versus infanticidal behavior in an activity-level-dependent manner. Through single-cell transcriptomic analysis, we found that molecular sex differences in the MeA are specifically represented in GABAergic neurons. Collectively, these results establish crucial roles for the MeA as a key node in the neural circuitry underlying pup-directed behaviors and provide important insight into the connection between sex differences across transcriptomes, cells, and circuits in regulating sexually dimorphic behavior.

中文翻译：

杏仁核内侧对父母教养行为的性别双态控制。

社会行为，包括针对年轻后代的行为，表现出惊人的性别差异。了解如何在回路和转录组水平上调节这些性二态性行为将提供对特定性别行为的神经机制的见解。在这里，我们发现内侧杏仁核（MeA）在控制父母行为和杀婴行为中具有性二态性。与传统观点相反，MeA中GABA能神经元的激活促进了女性的父母行为，而男性中该群体的激活以活性水平依赖性方式不同地促进了父母行为与杀婴行为。通过单细胞转录组分析，我们发现MeA中的分子性别差异在GABA能神经元中得到了特别的体现。总的来说，

更新日期：2019-02-14

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