A Facile-Synthesized Star Polycation Constructed as a Highly Efficient Gene Vector in Pest Management,ACS Sustainable Chemistry & Engineering

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A Facile-Synthesized Star Polycation Constructed as a Highly Efficient Gene Vector in Pest Management
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2019-02-13 00:00:00 , DOI: 10.1021/acssuschemeng.9b00004
Jianhao Li ₁ , Jin Qian ₂ , Yuanyuan Xu ₂ , Shuo Yan ₂ , Jie Shen ₂ , Meizhen Yin ₁

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Gene vectors have been extensively applied in various fields. However, the high economic cost of gene vectors limits their development and application, and there is an urgent demand for developing highly efficient gene vectors with low cost, especially for large-scale application. Here, we reported a simple but effective star polycation as a gene vector for pest management. Our polycation was constructed by commercial and cheap material sources, and the facile synthesis procedure was simplified to two reaction steps, decreasing the cost to a large extent. This vector showed a low cytotoxicity as well as a high gene delivery efficacy into live cells. The vector-doublestranded RNA (dsRNA) down-regulated the pest key developmental gene expression to inhibit the pest growth. Our work provides an efficient gene vector with low cost for scientific researches, which may also promote the practice and development of RNA interference (RNAi)-based pest management.

中文翻译：

一种高效合成的星型聚阳离子，可作为害虫治理中的高效基因载体

基因载体已广泛应用于各个领域。然而，基因载体的高经济成本限制了它们的开发和应用，并且迫切需要开发低成本的高效基因载体，特别是对于大规模应用。在这里，我们报道了一种简单而有效的星形聚阳离子作为有害生物管理的基因载体。我们的聚阳离子是由商业和廉价的材料来源构建的，并且易于合成的过程简化为两个反应步骤，从而在很大程度上降低了成本。该载体显示出低的细胞毒性以及向活细胞中的高基因递送功效。载体双链RNA（dsRNA）下调了有害生物关键发育基因的表达，从而抑制了有害生物的生长。

更新日期：2019-02-13

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