Cancer is the second most important cause of death worldwide. There is always a demand for new anticancer drugs and continuously a wide variety of natural and synthetic compounds were developed by the researchers. Nowadays, a large number of drugs in clinical practice were found to have a high incidence of side effect and multidrug conflict. The development of novel less toxic, low cost and very energetic N-methylpicolinamide-bearing hybrids is a hot research topic in the community of medicinal chemistry. Herein we highlight the current advances in the synthesis of picolinamide-containing heterocyclic compounds as potent anticancer agents. In addition, briefly explore their structure-activity relationship studies for the inspiration of the innovation and development of more potent and effective drugs against various death-causing cancer diseases.

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N-甲基吡啶甲基酰胺在抗癌治疗药物开发中的意义：合成和结构-活性关系（SAR）研究。

癌症是全球第二大最重要的死亡原因。一直对新的抗癌药物有需求，研究人员不断开发出各种各样的天然和合成化合物。如今，在临床实践中发现大量药物具有很高的副作用和多药冲突的发生率。新型低毒，低成本和高能N-甲基吡啶甲酸酰胺类杂种的开发是药物化学界的一个热门研究课题。在本文中，我们重点介绍了在合成含吡啶甲酸酰胺的杂环化合物作为有效抗癌剂方面的最新进展。此外，简要探讨它们的结构-活性关系研究，以启发创新和开发针对各种致死性癌症疾病的更有效的药物。