Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster
Organic Letters ( IF 4.9 ) Pub Date : 2019-02-12 00:00:00 , DOI: 10.1021/acs.orglett.9b00208
Changli Sun ₁ , Zhijie Yang _{1,

2} , Chunyan Zhang _{1,

2} , Zhiyong Liu ₃ , Jianqiao He _{1,

2} , Qing Liu _{1,

4} , Tianyu Zhang _{2,

3} , Jianhua Ju _{1,

2} , Junying Ma ₁

Affiliation

Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin’s structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey’s method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 μM, respectively.

中文翻译：

链霉菌SCSIO ZH16的基因组挖掘：阿曲霉素的发现及其生物合成基因簇的鉴定

深海来源的Atratus SCSIO ZH16深海链霉菌的基因组挖掘能够激活环二肽基因簇并分离其肉桂酸产物阿托霉素（1）。在广泛的光谱实验，X射线数据和Marfey方法的基础上阐明了阿曲霉素的结构。还提出并研究了合理的1的生物合成和定制修饰。此外，阿曲霉素还具有MIC分别为3.8和14.6μM的抗结核分枝杆菌H37Ra和H37Rv的活性。

更新日期：2019-02-12

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南