Oxytocin pathway gene networks in the human brain.,Nature Communications

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Oxytocin pathway gene networks in the human brain.
Nature Communications ( IF 14.7 ) Pub Date : 2019-02-08 , DOI: 10.1038/s41467-019-08503-8
Daniel S Quintana ₁ , Jaroslav Rokicki _{1,

2} , Dennis van der Meer ₁ , Dag Alnæs ₁ , Tobias Kaufmann ₁ , Aldo Córdova-Palomera ₁ , Ingrid Dieset ₁ , Ole A Andreassen ₁ , Lars T Westlye _{1,

2}

Affiliation

Oxytocin is a neuropeptide involved in animal and human reproductive and social behavior. Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR (oxytocin receptor), and CD38 (oxytocin secretion). Here, we characterized the distribution of OXT, OXTR, and CD38 mRNA across the human brain by creating voxel-by-voxel volumetric expression maps, and identified putative gene pathway interactions by comparing gene expression patterns across 20,737 genes. Expression of the three selected oxytocin pathway genes was enriched in subcortical and olfactory regions and there was high co-expression with several dopaminergic and muscarinic acetylcholine genes, reflecting an anatomical basis for critical gene pathway interactions. fMRI meta-analysis revealed that the oxytocin pathway gene maps correspond with the processing of anticipatory, appetitive, and aversive cognitive states. The oxytocin signaling system may interact with dopaminergic and muscarinic acetylcholine signaling to modulate cognitive state processes involved in complex human behaviors.

中文翻译：

人脑中的催产素途径基因网络。

催产素是一种涉及动物和人类生殖和社会行为的神经肽。三种催产素信号转导基因经常与人类的社会行为有关：OXT（催产素的结构基因），OXTR（催产素受体）和CD38（催产素分泌）。在这里，我们通过创建逐个体素的体积表达图来表征OXT，OXTR和CD38 mRNA在人脑中的分布，并通过比较20737个基因的基因表达模式来确定推定的基因途径相互作用。三种选择的催产素途径基因的表达在皮层下和嗅觉区域富集，并且与几个多巴胺能和毒蕈碱型乙酰胆碱基因具有高共表达，反映出关键基因途径相互作用的解剖学基础。fMRI荟萃分析显示催产素途径基因图谱与预期，食欲和厌恶认知状态的处理相对应。催产素信号系统可以与多巴胺能和毒蕈碱型乙酰胆碱信号传导相互作用，以调节复杂人类行为中涉及的认知状态过程。

更新日期：2019-02-08

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