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Silk Fibroin Hydrogels: Enhanced Osteogenesis of Bone Marrow‐Derived Mesenchymal Stem Cells by a Functionalized Silk Fibroin Hydrogel for Bone Defect Repair (Adv. Healthcare Mater. 3/2019)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-02-07 , DOI: 10.1002/adhm.201970006
Yufei Yan 1 , Baochang Cheng 2 , Kaizhe Chen 1 , Wenguo Cui 1 , Jin Qi 1 , Xinming Li 2 , Lianfu Deng 1
Affiliation  

Manuscript number 1801043 by Jin Qi, Xinming Li, and co‐workers illustrates that the integration of silk fibroin proteins from domesticated silkworms (B. mori) and a small peptide gelator (NapFFRGD) can work as an effective means for the generation of a novel bioactive hydrogel with high biocompatibility, slow biodegradation rate, and good cell‐adhesive properties, compared to other traditional methods. More importantly, because of the presence of RGD ligands within the gel matrix, the resulting hydrogel is capable of forming favorable microenvironments, and inherently inducing the differentiation of bone marrow‐derived mesenchymal stem cells for bone regeneration.
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中文翻译:

丝素蛋白水凝胶:通过功能化的丝素蛋白水凝胶增强的骨髓源间充质干细胞成骨作用(Adv。Healthcare Mater。3/2019)

Jin Qi,Li Xinming Li及其同事的手稿编号1801043说明,将家养蚕(B. mori)的蚕丝蛋白蛋白与小肽胶凝剂(NapFFRGD)整合起来可以作为产生新型抗体的有效手段与其他传统方法相比,具有高生物相容性,缓慢的生物降解速率和良好的细胞粘附特性的生物活性水凝胶。更重要的是,由于凝胶基质内存在RGD配体,因此生成的水凝胶能够形成有利的微环境,并固有地诱导骨髓来源的间充质干细胞分化为骨再生。
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更新日期:2019-02-07
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