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A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-02-04 , DOI: 10.1002/adhm.201801147 Amanda N. Steele 1, 2 , Lyndsay M. Stapleton 1, 2 , Justin M. Farry 2 , Haley J. Lucian 2 , Michael J. Paulsen 2 , Anahita Eskandari 2 , Camille E. Hironaka 2 , Akshara D. Thakore 2 , Hanjay Wang 2 , Anthony C. Yu 3 , Doreen Chan 3 , Eric A. Appel 3 , Yiping Joseph Woo 1, 2
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-02-04 , DOI: 10.1002/adhm.201801147 Amanda N. Steele 1, 2 , Lyndsay M. Stapleton 1, 2 , Justin M. Farry 2 , Haley J. Lucian 2 , Michael J. Paulsen 2 , Anahita Eskandari 2 , Camille E. Hironaka 2 , Akshara D. Thakore 2 , Hanjay Wang 2 , Anthony C. Yu 3 , Doreen Chan 3 , Eric A. Appel 3 , Yiping Joseph Woo 1, 2
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Hydrogels have emerged as a diverse class of biomaterials offering a broad range of biomedical applications. Specifically, injectable hydrogels are advantageous for minimally invasive delivery of various therapeutics and have great potential to treat a number of diseases. However, most current injectable hydrogels are limited by difficult and time‐consuming fabrication techniques and are unable to be delivered through long, narrow catheters, preventing extensive clinical translation. Here, the development of an easily‐scaled, catheter‐injectable hydrogel utilizing a polymer–nanoparticle crosslinking mechanism is reported, which exhibits notable shear‐thinning and self‐healing behavior. Gelation of the hydrogel occurs immediately upon mixing the biochemically modified hyaluronic acid polymer with biodegradable nanoparticles and can be easily injected through a high‐gauge syringe due to the dynamic nature of the strong, yet reversible crosslinks. Furthermore, the ability to deliver this novel hydrogel through a long, narrow, physiologically‐relevant catheter affixed with a 28‐G needle is highlighted, with hydrogel mechanics unchanged after delivery. Due to the composition of the gel, it is demonstrated that therapeutics can be differentially released with distinct elution profiles, allowing precise control over drug delivery. Finally, the cell‐signaling and biocompatibility properties of this innovative hydrogel are demonstrated, revealing its wide range of therapeutic applications.
中文翻译：
用于原位组织工程的生物相容性治疗用导管可递送水凝胶
水凝胶已经成为提供多种生物医学应用的多种生物材料。具体而言，可注射水凝胶有利于以微创方式递送各种治疗剂，并且具有治疗多种疾病的巨大潜力。但是，大多数当前的可注射水凝胶受到困难且费时的制造技术的限制，无法通过细长的细长导管进行输送，从而无法进行广泛的临床翻译。在这里，据报道利用聚合物-纳米粒子交联机理开发了易于缩放，可导管注射的水凝胶，该凝胶表现出显着的剪切稀化和自愈特性。将生物化学改性的透明质酸聚合物与可生物降解的纳米粒子混合后，水凝胶立即发生凝胶化，由于强而可逆的交联的动态特性，可通过高规格注射器轻松注入。此外，突出了通过带有28G针头的细长，生理相关导管输送这种新型水凝胶的能力，水凝胶力学在输送后保持不变。由于凝胶的组成，已证明治疗剂可以不同的洗脱曲线差异释放，从而可以精确控制药物的递送。最后，展示了这种创新水凝胶的细胞信号传导和生物相容性，揭示了其广泛的治疗应用。
更新日期：2019-02-04
中文翻译：
用于原位组织工程的生物相容性治疗用导管可递送水凝胶
水凝胶已经成为提供多种生物医学应用的多种生物材料。具体而言，可注射水凝胶有利于以微创方式递送各种治疗剂，并且具有治疗多种疾病的巨大潜力。但是，大多数当前的可注射水凝胶受到困难且费时的制造技术的限制，无法通过细长的细长导管进行输送，从而无法进行广泛的临床翻译。在这里，据报道利用聚合物-纳米粒子交联机理开发了易于缩放，可导管注射的水凝胶，该凝胶表现出显着的剪切稀化和自愈特性。将生物化学改性的透明质酸聚合物与可生物降解的纳米粒子混合后，水凝胶立即发生凝胶化，由于强而可逆的交联的动态特性，可通过高规格注射器轻松注入。此外，突出了通过带有28G针头的细长，生理相关导管输送这种新型水凝胶的能力，水凝胶力学在输送后保持不变。由于凝胶的组成，已证明治疗剂可以不同的洗脱曲线差异释放，从而可以精确控制药物的递送。最后，展示了这种创新水凝胶的细胞信号传导和生物相容性，揭示了其广泛的治疗应用。
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