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Hydrophilic Carbon Nanomaterials: Characterisation by Physical, Chemical, and Biological Assays.
ChemMedChem ( IF 3.6 ) Pub Date : 2019-02-22 , DOI: 10.1002/cmdc.201900003 Andreia D Veloso 1 , Ana M Ferraria 2 , Ana M Botelho do Rego 2 , Pedro B Tavares 1 , Patrícia Valentão 3 , David D Pereira 3 , Paula B Andrade 3 , António J Fernandes 4 , Maria C Oliveira 1 , Romeu A Videira 3
ChemMedChem ( IF 3.6 ) Pub Date : 2019-02-22 , DOI: 10.1002/cmdc.201900003 Andreia D Veloso 1 , Ana M Ferraria 2 , Ana M Botelho do Rego 2 , Pedro B Tavares 1 , Patrícia Valentão 3 , David D Pereira 3 , Paula B Andrade 3 , António J Fernandes 4 , Maria C Oliveira 1 , Romeu A Videira 3
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A highly hydrophilic carbon nanomaterial was generated by using an electrochemical approach, and its structure, chemical composition, redox properties, antioxidant activity and effects on cells were characterised. It was found that the nanomaterial possesses a structure dominated by sp2 carbon atoms in a non-ordered carbon network formed by small clusters (<2 nm) of a carbonaceous material. This material has an outstanding capability for donating electrons and an unusual ability to bind metal cations. Antioxidant activity assays showed that it displays a high scavenging activity against both 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, and a concentration-dependent ability to protect mitochondrial lipids and intracellular thiol groups from oxidation promoted by external oxidising agents. Cell-based assays also revealed that the nanomaterial has the ability to protect neuronal cells against oxidative damage and toxicity promoted by tert-butyl hydroperoxide and amyloid-β1-42 peptide. These results, combined with the attractive methodology for generating this hydrophilic carbon-based nanomaterial, make this study the first step in addressing the therapeutic application of this new material.
中文翻译：
亲水碳纳米材料：通过物理，化学和生物分析表征。
采用电化学方法制备了高度亲水的碳纳米材料，并对其结构，化学组成，氧化还原特性，抗氧化活性以及对细胞的影响进行了表征。发现纳米材料在由碳质材料的小簇（＜2nm）形成的无序碳网络中具有由sp 2碳原子为主的结构。这种材料具有出色的供电能力和非凡的结合金属阳离子的能力。抗氧化活性测定表明，它对2,2,2-二苯基-1-吡啶并肼基和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）自由基均具有较高的清除活性，并且具有浓度依赖性的抗氧化能力。保护线粒体脂质和细胞内巯基免受外部氧化剂促进的氧化。基于细胞的分析还表明，纳米材料具有保护神经元细胞免受叔丁基氢过氧化物和淀粉样蛋白β1-42促进的氧化损伤和毒性的能力。这些结果，与产生这种亲水性碳基纳米材料的有吸引力的方法相结合，使这项研究成为解决这种新材料的治疗应用的第一步。
更新日期：2019-02-22
中文翻译：
亲水碳纳米材料：通过物理，化学和生物分析表征。
采用电化学方法制备了高度亲水的碳纳米材料，并对其结构，化学组成，氧化还原特性，抗氧化活性以及对细胞的影响进行了表征。发现纳米材料在由碳质材料的小簇（＜2nm）形成的无序碳网络中具有由sp 2碳原子为主的结构。这种材料具有出色的供电能力和非凡的结合金属阳离子的能力。抗氧化活性测定表明，它对2,2,2-二苯基-1-吡啶并肼基和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）自由基均具有较高的清除活性，并且具有浓度依赖性的抗氧化能力。保护线粒体脂质和细胞内巯基免受外部氧化剂促进的氧化。基于细胞的分析还表明，纳米材料具有保护神经元细胞免受叔丁基氢过氧化物和淀粉样蛋白β1-42促进的氧化损伤和毒性的能力。这些结果，与产生这种亲水性碳基纳米材料的有吸引力的方法相结合，使这项研究成为解决这种新材料的治疗应用的第一步。
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