Redox-Controlled Voltage Responsive Micelles Assembled by Noncovalently Grafted Polymers for Controlled Drug Release,Macromolecules

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Redox-Controlled Voltage Responsive Micelles Assembled by Noncovalently Grafted Polymers for Controlled Drug Release
Macromolecules ( IF 5.1 ) Pub Date : 2019-02-04 00:00:00 , DOI: 10.1021/acs.macromol.8b02641
Zhenyu Yuan ₁ , Jie Wang ₁ , Yiming Wang ₁ , Yujie Zhong ₁ , Xinsheng Zhang ₁ , Li Li ₁ , Junyou Wang ₁ , Stephen F. Lincoln ₂ , Xuhong Guo _{1,

3}

Affiliation

Voltage responsive micelles prepared from noncovalently grafted amphiphilic polymers were reported. The noncovalent amphiphilic polymers were prepared through the host–guest interaction between β-cyclodextrin (β-CD) grafted dextran (Dex-CD) and ferrocene (Fc) terminated poly(ε-caprolactone) (PCL-Fc). Because of the presence of Fc groups, the inclusion complex between Fc and β-CD can be reversibly controlled by an external stimulating voltage, leading to reversible formation and disassembly of the micelles. The occurrence of the inclusion complex between Fc and β-CD was confirmed by cyclic voltammetry (CV) and the 2D NOESY spectrum. Furthermore, meloxicam was selected as a model drug to test the controlled release performance of these voltage responsive micelles. It was found that the release rate and the final cumulative release amount of meloxicam can be effectively controlled by the external voltage, which may be of use in controlled drug delivery.

中文翻译：

由非共价接枝聚合物组装的氧化还原控制的电压响应胶束，用于药物的控制释放

报道了由非共价接枝的两亲聚合物制备的电压响应胶束。非共价两亲性聚合物是通过β-环糊精（β-CD）接枝的葡聚糖（Dex-CD）和二茂铁（Fc）封端的聚（ε-己内酯）（PCL-Fc）之间的客体相互作用而制备的。由于Fc基团的存在，可以通过外部刺激电压可逆地控制Fc和β-CD之间的包合物，导致胶束的可逆形成和分解。通过循环伏安法（CV）和二维NOESY光谱确认了Fc和β-CD之间包含包合物的存在。此外，选择美洛昔康作为模型药物来测试这些电压响应胶束的控释性能。

更新日期：2019-02-04

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