Isolation of 11,12-seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain,Organic Letters

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Isolation of 11,12-seco-Rifamycin W Derivatives Reveals a Cleavage Pattern of the Rifamycin Ansa Chain
Organic Letters ( IF 4.9 ) Pub Date : 2019-02-04 00:00:00 , DOI: 10.1021/acs.orglett.8b03792
Yanrong Shi ₁ , Juanli Zhang ₂ , Xiuyu Tian ₁ , Xingkang Wu _{1,

3} , Tianhong Li ₁ , Chunhua Lu ₁ , Yuemao Shen _{1,

4}

Affiliation

This study reported the isolation and characterization of 11 rifamycin congeners including six new ones (1–6) from the agar fermentation extract of Amycolatopsis mediterranei S699. Compounds 1 and 2 are rifamycin glycosides named as rifamycinosides A and B, respectively. Their polyketide skeleton represents a novel cleavage pattern of the rifamycin ansa chain. Compounds 6 and 8 showed potential T3SS inhibitory activity, and 6 induced G2/M phase arrest and caused DNA damage in HCT116 cells.

中文翻译：

的11,12-隔离塞科-RifamycinW¯¯衍生品揭示了利福霉素的切割模式安莎链

该研究报告的11个利福霉素同源物的分离和表征包括6级新的（1 - 6）从琼脂的发酵提取物拟无枝酸地中海S699。化合物1和2分别是利福霉素糖苷，分别称为利福霉素苷A和B。它们的聚酮骨架代表利福霉素ansa链的新型裂解模式。化合物6和8显示出潜在T3SS的抑制活性，和6引起的G2 / M期阻滞和引起DNA损伤在HCT116细胞。

更新日期：2019-02-04

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