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Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2019-02-04 00:00:00 , DOI: 10.1021/acssuschemeng.8b05658 Ghada Hassan 1 , Nina Forsman 2 , Xing Wan 3 , Leena Keurulainen 1 , Luis M. Bimbo 4 , Leena-Sisko Johansson 2 , Nina Sipari 5 , Jari Yli-Kauhaluoma 1 , Ralf Zimmermann 6 , Susanne Stehl 6 , Carsten Werner 6 , Per E. J. Saris 3 , Monika Österberg 2 , Vânia M. Moreira 1, 4
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2019-02-04 00:00:00 , DOI: 10.1021/acssuschemeng.8b05658 Ghada Hassan 1 , Nina Forsman 2 , Xing Wan 3 , Leena Keurulainen 1 , Luis M. Bimbo 4 , Leena-Sisko Johansson 2 , Nina Sipari 5 , Jari Yli-Kauhaluoma 1 , Ralf Zimmermann 6 , Susanne Stehl 6 , Carsten Werner 6 , Per E. J. Saris 3 , Monika Österberg 2 , Vânia M. Moreira 1, 4
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The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 105 colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.
中文翻译：
基于脱氢松香胺的纤维素纳米原纤维膜：一类新型的可持续生物材料，具有高效，广谱的抗菌作用
作为高级生物材料不可或缺的一部分，抗菌表面的设计如今已成为研究的重中之重，因为微生物在表面上的积累给卫生和工业部门带来了沉重的成本。目前，人们越来越感兴趣的是从自然界中丰富的聚合物（例如纤维素）设计功能材料，这些材料将可持续性与出色的机械性能和经济生产结合在一起。由于环境毒性和对金属抗菌剂的耐药性扩散，还需要找到抗菌的银基试剂的合适替代品。在此，我们报道了用脱氢松香胺1（CNF-CMC-1），以提供创新的接触活性表面活性，以对抗革兰氏阳性和革兰氏阴性细菌，包括耐甲氧西林的金黄色葡萄球菌MRSA14TK301，具有低传播阻力和良好的生物相容性，所有这些都通过低表面覆盖率实现。CNF-CMC-1对金黄色葡萄球菌ATCC12528特别有效，可导致总细胞从10 5完全减少接触24小时后，菌落形成单位（CFU）/ mL细菌悬液。CNF表面的这种温和的化学修饰完全保留了原始薄膜的有益特性，包括湿气缓冲和强度，这与许多潜在的应用有关。我们最初设计的表面代表了一类新型的生态友好型生物材料，可通过添加抗菌特性而不需要对环境有毒的银来优化CNF的性能。
更新日期：2019-02-04
中文翻译：
基于脱氢松香胺的纤维素纳米原纤维膜：一类新型的可持续生物材料，具有高效，广谱的抗菌作用
作为高级生物材料不可或缺的一部分，抗菌表面的设计如今已成为研究的重中之重，因为微生物在表面上的积累给卫生和工业部门带来了沉重的成本。目前，人们越来越感兴趣的是从自然界中丰富的聚合物（例如纤维素）设计功能材料，这些材料将可持续性与出色的机械性能和经济生产结合在一起。由于环境毒性和对金属抗菌剂的耐药性扩散，还需要找到抗菌的银基试剂的合适替代品。在此，我们报道了用脱氢松香胺1（CNF-CMC-1），以提供创新的接触活性表面活性，以对抗革兰氏阳性和革兰氏阴性细菌，包括耐甲氧西林的金黄色葡萄球菌MRSA14TK301，具有低传播阻力和良好的生物相容性，所有这些都通过低表面覆盖率实现。CNF-CMC-1对金黄色葡萄球菌ATCC12528特别有效，可导致总细胞从10 5完全减少接触24小时后，菌落形成单位（CFU）/ mL细菌悬液。CNF表面的这种温和的化学修饰完全保留了原始薄膜的有益特性，包括湿气缓冲和强度，这与许多潜在的应用有关。我们最初设计的表面代表了一类新型的生态友好型生物材料，可通过添加抗菌特性而不需要对环境有毒的银来优化CNF的性能。
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