Copper(II) Triflate Catalyzed Regioselective and Enantioselective Propargylation of Isatin Derivatives by Using Allenylboronic Acid Pinacol Ester,European Journal of Organic Chemistry

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Copper(II) Triflate Catalyzed Regioselective and Enantioselective Propargylation of Isatin Derivatives by Using Allenylboronic Acid Pinacol Ester
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-03-22 , DOI: 10.1002/ejoc.201701745
Naveen Gupta _{1,

2} , Rajkumar Tak _{1,

2} , Mohd Nazish _{1,

2} , Ajay Jakhar _{1,

2} , Noor-ul H. Khan _{1,

2} , Rukhsana I. Kureshy _{1,

2}

Affiliation

Regioselective propargylation of isatins in aqueous media. With this protocol we could achieve propargyl alcohols in high yields with wide substrate scope. The enantioselective version was also explored to yield chiral alcohols with er up to 12:88, which is reported for the first time.