A Near-Infrared (NIR) ratiometric and on-off fluorescent probe 1 was synthesized, which exhibited high sensitivity and excellent selectivity in arginine (Arg) recognition. 1 can quantitatively detect Arg in concentration range from 0 to 150 μM with the LOD of 138 nM. Further, it displayed excellent selectivity and anti-interference over many biological species, metal ions and anions. Due to its ability to target lysosome, the response of Arg to this probe in a living cell was successfully tracked in a ratiometric manner via fluorescence imaging.

中文翻译：

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一种新型半菁衍生物的近红外比率荧光检测溶酶体中的精氨酸

合成了近红外（NIR）定量和开关荧光探针1，该探针在精氨酸（Arg）识别中表现出高灵敏度和出色的选择性。1可以定量检测浓度范围为0至150μM的Arg，LOD为138 nM。此外，它对许多生物物种，金属离子和阴离子显示出极好的选择性和抗干扰性。由于其靶向溶酶体的能力，在活细胞中Arg对这种探针的反应已通过荧光成像按比例方式成功进行了追踪。