Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents.

中文翻译：

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异吲哚衍生物：突出的抗癌结构基序。

异吲哚衍生物构成一类重要的生物活性杂环化合物，由于其多样化的药理特性（例如抗微生物剂，驱虫药，杀虫剂，环加氧酶同工酶（COX-2）和凝血酶抑制作用，尤其是其抗癌活性）而继续引起人们的广泛关注。这篇综述着重介绍了异吲哚衍生物及其相关结构的抗癌特性，并希望这将有助于进一步为合理设计和开发功能更强，毒性更小的抗癌剂提供新的思路。