A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond.

中文翻译：

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新型手性1-（3-氯吡啶-2-基）-3-（三氟甲基）-1 H-吡唑-4-羧酰胺衍生物的合成，杀线活性和对接研究

设计并合成了一系列新颖的手性氟化吡唑羧酰胺衍生物。所有这些标题化合物均通过NMR和MS确认。初步杀线虫活性结果表明，其中一些对由南方根结线虫引起的番茄根结线虫病表现出良好的防治效果。对接结果表明，化合物5n通过氢键与AchE的氨基酸残基Tyr 121，Trp 279相互作用。