Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a C_max at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane.

中文翻译：

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口服马齿Extract提取物后大鼠体内的奥替酰胺和醋酸奥替酰胺的药代动力学和生物分布

嘌呤酰胺和乙酸戊酰胺是马齿sl（Portulaca oleracea L.）的主要活性成分，马齿an是一种具有各种生物活性的食用植物。在这项研究中，我们开发了一种经过验证的UHPLC-MS / MS方法，用于定量大鼠血浆和各种器官组织中的aurantiamide和乙酸aurantiamide浓度，以此为基础来研究它们在体内的药理特性和分布。口服给药后，Aurantiamide和乙酸Aurantiamide迅速吸收，均达到C _max在0.2小时左右。它们的代谢程度在不同器官组织之间也不同，给药后4小时浓度降低约90％，因此在组织中没有长期积累。这是第一个研究大鼠琥珀酰胺和醋酸琥珀酰胺的药代动力学和生物分布的研究，我们的工作可能是研究与马齿sl生物活性相关的潜在机制的第一步。