Chemically-defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: a comparative analysis,Journal of the American Chemical Society

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Chemically-defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: a comparative analysis
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-01-27 , DOI: 10.1021/jacs.7b13361
Samuele Cazzamalli ₁ , Alberto Dal Corso ₁ , Fontaine Widmayer ₁ , Dario Neri ₁

Affiliation

We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.

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