Alkylation of sodium 4(5)-alkyl-6-oxo-1,6-dihydropyrimidine-2-thiolates with 2-bromo-1-(4-bromophenyl)ethan-1-one afforded 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}pyrimidin-4(3H)-ones. Analogous reaction with sodium 4-trifluoromethyl-6-oxo-1,6-dihydropyrimidine-2-thiolate gave a mixture of 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}-4-(trifluoromethyl)pyrimidin-4(3H)-one and its intramolecular cyclization product, 3-(4-bromophenyl)-3-hydroxy-7-trifluoromethyl-2,3-dihydro[1,3]thiazolo[3,2-a]-pyrimidin-5-one.

中文翻译：

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2-{[2-（4-溴苯基）-2-氧乙基]硫烷基}嘧啶-4（3 h）-ones的合成与杂环化

用2-溴-1-（4-溴苯基）乙-1-酮将4（5）-烷基-6-氧代-1,6-二氢嘧啶-2-硫醇钠烷基化，得到2-{[2-（4-溴苯基）-2-氧代乙基]硫烷基}嘧啶-4（3 H）-ones。与4-三氟甲基-6-氧代-1，6-二氢嘧啶-2-硫醇钠的类似反应，得到2-{[2-（4-溴苯基）-2-氧代乙基]硫烷基} -4-（三氟甲基）嘧啶的混合物-4（3 H）-one及其分子内环化产物3-（4-溴苯基）-3-羟基-7-三氟甲基-2,3-二氢[1,3]噻唑并[3,2- a ]-嘧啶-5-一个