Food-derived bioactive peptides may have various physiological modulatory and regulatory functions and are now being studied extensively. Recently, the novel dipeptide Tyr-Ala was isolated from hydrolyzed maize protein. Tyr-Ala significantly prolonged the lifespan of wild-type Caenorhabditis elegans and extended the nematode healthspan and lifespan during heat/oxidative stress. Compared with its constituent amino acids, Tyr-Ala was more efficient in enhancing stress resistance. Further studies demonstrated that the significant longevity-extending effects of Tyr-Ala on Caenorhabditis elegans were attributed to its in vitro and in vivo free radical-scavenging effects, in addition to its ability to up-regulate stress resistance-related proteins, such as SOD (Superoxide Dismutase)-3 and HSP (Heat Shock Protein)-16.2. Real-time PCR results showed that the up-regulation of aging-associated genes, such as daf-16, sod-3, hsp-16.2 and skn-1, also contributed to the stress-resistance effect of Tyr-Ala. These results indicate that the novel dipeptide Tyr-Ala can protect against external stress and thus extend the lifespan and healthspan of Caenorhabditis elegans. Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research.

中文翻译：

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新型二肽Tyr-Ala（TA）可显着提高秀丽隐杆线虫的寿命和健康程度†

食物来源的生物活性肽可能具有多种生理调节和调节功能，目前正在广泛研究中。最近，从水解的玉米蛋白中分离了新型的二肽Tyr-Ala。Tyr-Ala显着延长了野生型秀丽隐杆线虫的寿命，并延长了热/氧化胁迫下线虫的健康寿命和寿命。与其组成氨基酸相比，Tyr-Ala在增强抗逆性方面更有效。进一步的研究表明，Tyr-Ala对秀丽隐杆线虫的显着延长寿命的作用归因于其体外和体内作用清除自由基的作用，除了具有上调抗压力相关蛋白（如SOD（超氧化物歧化酶）-3和HSP（热休克蛋白）-16.2）的能力之外。实时PCR结果显示，与衰老相关的基因如daf-16，sod-3，hsp-16.2和skn-1的上调也有助于Tyr-Ala的抗逆作用。这些结果表明，新型二肽Tyr-Ala可以抵抗外界压力，从而延长秀丽隐杆线虫的寿命和健康寿命。因此，Tyr-Ala可以用作抗衰老研究中的潜在药物。