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Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1021/acsami.7b14193 Haihong Li , Ruoyan Wei , Gui-Hua Yan , Ji Sun , Chunju Li , Haifang Wang , Liyi Shi , John A. Capobianco 1 , Lining Sun
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1021/acsami.7b14193 Haihong Li , Ruoyan Wei , Gui-Hua Yan , Ji Sun , Chunju Li , Haifang Wang , Liyi Shi , John A. Capobianco 1 , Lining Sun
Affiliation
Exploring novel drug delivery systems with good stability and new structure to integrate pillararene and upconversion nanoparticles (UCNPs) into one system continues to be an important challenge. Herein, we report a novel preparation of a supramolecular upconversion nanosystem via the host–guest complexation based on carboxylate-based pillar[5]arene (WP5) and 15-carboxy-N,N,N-trialkylpentadecan-1-ammonium bromide (1)-functionalized UCNPs to produce WP5⊃1-UCNPs that can be loaded with the chemotherapeutic drug doxorubicin (DOX). Importantly, the WP5 on the surface of the drug-loaded nanosystem can be efficiently protonated under acidic conditions, resulting in the collapse of the nanosystem and drug release. Moreover, cellular uptake confirms that the nanosystem can enter human cervical cancer (HeLa) cells, resulting in drug accumulation in the cells. More importantly, cytotoxicity experiments demonstrated the excellent biocompatibility of WP5⊃1-UCNPs without loading DOX and that the nanosystem DOX-WP5⊃1-UCNPs exhibited an ability of killing HeLa cells effectively. We also investigated magnetic resonance imaging and upconversion luminescence imaging, which may be employed as visual imaging agents in cancer diagnosis and treatment. Thus, in the present work, we show a simple yet powerful strategy to combine UCNPs and pillar[5]arene to produce a unified nanosystem for dual-mode bioimaging-guided therapeutic applications.
中文翻译:
基于水溶性紫罗兰和稀土掺杂上转换纳米粒子的智能自组装纳米系统,用于pH响应药物的递送
探索具有良好稳定性和新结构的新型药物递送系统,以将柱状碳烯和上转换纳米粒子(UCNP)集成到一个系统中,仍然是一个重要的挑战。在这里,我们报道了一种新的超分子上转换纳米系统的制备方法,该系统是通过基于羧酸盐基柱[5]芳烃(WP5)和15-羧基-N,N,N-三烷基十五烷基-1-溴化铵的主客体络合制备的(1) -功能化UCNPs产生WP5⊃ 1可以装载化疗药物阿霉素(DOX)的-UCNP。重要的是,可以在酸性条件下有效地使载药纳米系统表面上的WP5质子化,从而导致纳米系统崩溃和药物释放。此外,细胞摄取证实了纳米系统可以进入人类宫颈癌(HeLa)细胞,导致药物在细胞中积聚。更重要的是,细胞毒性实验表明WP5⊃的优异的生物相容性1个无负载DOX和-UCNPs的纳米系统DOX-WP5⊃ 1-UCNPs具有有效杀死HeLa细胞的能力。我们还研究了磁共振成像和上转换发光成像,它们可以用作视觉成像剂用于癌症的诊断和治疗。因此,在目前的工作中,我们展示了一种简单而强大的策略,可以将UCNPs和支柱[5]芳烃结合起来,为双模生物成像引导的治疗应用生产统一的纳米系统。
更新日期:2018-01-24
中文翻译:
基于水溶性紫罗兰和稀土掺杂上转换纳米粒子的智能自组装纳米系统,用于pH响应药物的递送
探索具有良好稳定性和新结构的新型药物递送系统,以将柱状碳烯和上转换纳米粒子(UCNP)集成到一个系统中,仍然是一个重要的挑战。在这里,我们报道了一种新的超分子上转换纳米系统的制备方法,该系统是通过基于羧酸盐基柱[5]芳烃(WP5)和15-羧基-N,N,N-三烷基十五烷基-1-溴化铵的主客体络合制备的(1) -功能化UCNPs产生WP5⊃ 1可以装载化疗药物阿霉素(DOX)的-UCNP。重要的是,可以在酸性条件下有效地使载药纳米系统表面上的WP5质子化,从而导致纳米系统崩溃和药物释放。此外,细胞摄取证实了纳米系统可以进入人类宫颈癌(HeLa)细胞,导致药物在细胞中积聚。更重要的是,细胞毒性实验表明WP5⊃的优异的生物相容性1个无负载DOX和-UCNPs的纳米系统DOX-WP5⊃ 1-UCNPs具有有效杀死HeLa细胞的能力。我们还研究了磁共振成像和上转换发光成像,它们可以用作视觉成像剂用于癌症的诊断和治疗。因此,在目前的工作中,我们展示了一种简单而强大的策略,可以将UCNPs和支柱[5]芳烃结合起来,为双模生物成像引导的治疗应用生产统一的纳米系统。