Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device,Advanced Healthcare Materials

当前位置： X-MOL 学术 › Adv. Healthcare Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enzyme‐Based Glucose Sensor: From Invasive to Wearable Device
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-15 , DOI: 10.1002/adhm.201701150
Hyunjae Lee _{1,

2} , Yongseok Joseph Hong _{1,

2} , Seungmin Baik _{1,

2} , Taeghwan Hyeon _{1,

2} , Dae‐Hyeong Kim _{1,

2}

Affiliation

Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research‐level devices from simple test strips to wearable devices and implantable systems. Although directly monitoring blood glucose assures accurate information, the invasive needle‐pinching step to collect blood often results in patients (particularly young patients) being reluctant to adopt the process. An implantable glucose sensor may avoid the burden of repeated blood collections, but it is quite invasive and requires periodic replacement of the sensor owing to biofouling and its short lifetime. Therefore, noninvasive methods to estimate blood glucose levels from tears, saliva, interstitial fluid (ISF), and sweat are currently being studied. This review discusses the evolution of enzyme‐based electrochemical glucose sensors, including materials, device structures, fabrication processes, and system engineering. Furthermore, invasive and noninvasive blood glucose monitoring methods using various biofluids or blood are described, highlighting the recent progress in the development of enzyme‐based glucose sensors and their integrated systems.

中文翻译：

基于酶的葡萄糖传感器：从有创设备到可穿戴设备

血糖浓度是患者健康的关键指标，尤其是与糖尿病有关的症状。由于大量的糖尿病患者，已经研究了许多葡萄糖测量方法以实现连续和准确的葡萄糖水平监测。其中，电化学分析之所以突出是因为它既简单又定量。从简单的测试条到可穿戴设备和可植入系统，该技术已被纳入商业化和研究级别的设备中。尽管直接监测血糖可确保获得准确的信息，但侵入性的针刺采血步骤通常会导致患者（尤其是年轻患者）不愿采用该过程。植入式葡萄糖传感器可以避免重复采血的负担，但是由于生物污损和使用寿命短，它具有很大的侵入性，并且需要定期更换传感器。因此，目前正在研究通过眼泪，唾液，间质液（ISF）和汗液估算血糖水平的非侵入性方法。这篇综述讨论了基于酶的电化学葡萄糖传感器的发展，包括材料，设备结构，制造工艺和系统工程。此外，还描述了使用各种生物流体或血液的侵入性和非侵入性血糖监测方法，突出了基于酶的葡萄糖传感器及其集成系统的最新进展。目前正在研究组织液（ISF）和汗液。这篇综述讨论了基于酶的电化学葡萄糖传感器的发展，包括材料，设备结构，制造工艺和系统工程。此外，还描述了使用各种生物流体或血液的侵入性和非侵入性血糖监测方法，突出了基于酶的葡萄糖传感器及其集成系统的最新进展。目前正在研究组织液（ISF）和汗液。这篇综述讨论了基于酶的电化学葡萄糖传感器的发展，包括材料，设备结构，制造工艺和系统工程。此外，还描述了使用各种生物流体或血液的侵入性和非侵入性血糖监测方法，突出了基于酶的葡萄糖传感器及其集成系统的最新进展。

更新日期：2018-01-15

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南