[4 + 2] Cyclization of para-Quinone Methide Derivatives with Alkynes,The Journal of Organic Chemistry

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[4 + 2] Cyclization of para-Quinone Methide Derivatives with Alkynes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1021/acs.joc.7b02942
Guang-Jian Mei ₁ , Shao-Li Xu ₁ , Wen-Qin Zheng ₁ , Chen-Yu Bian ₁ , Feng Shi ₁

Affiliation

The first cyclization of para-quinone methide derivatives with alkynes was established by utilizing the [4 + 2] reaction of ortho-hydroxyphenyl-substituted para-quinone methides with ynones or benzyne, which efficiently constructed the scaffolds of chromene and xanthene in high yields (up to 88%). This protocol has not only fulfilled the task of developing cyclization reactions of para-quinone methide derivatives but also provided an efficient method for constructing chromene and xanthene scaffolds.

中文翻译：

[4 + 2]对炔基甲基对甲醌衍生物的环化

利用对羟基苯酚取代的对苯醌甲基化物与炔酮或苯炔的[4 + 2]反应，建立了炔烃与对炔基甲基化物衍生物的第一个环化反应，该反应有效地构建了高产的色烯和x吨骨架（高达88％）。该方案不仅完成了开发对苯醌甲基化物衍生物的环化反应的任务，而且为构建亚甲基和氧杂蒽骨架提供了一种有效的方法。

更新日期：2018-01-24

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