Advances in One-Pot Synthesis through Borrowing Hydrogen Catalysis,Chemical Reviews

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Advances in One-Pot Synthesis through Borrowing Hydrogen Catalysis
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1021/acs.chemrev.7b00340
Avelino Corma ₁ , Javier Navas ₁ , Maria J. Sabater ₁

Affiliation

The borrowing hydrogen (BH) principle, also called hydrogen auto-transfer, is a powerful approach which combines transfer hydrogenation (avoiding the direct use of molecular hydrogen) with one or more intermediate reactions to synthesize more complex molecules without the need for tedious separation or isolation processes. The strategy which usually relies on three steps, (i) dehydrogenation, (ii) intermediate reaction, and (iii) hydrogenation, is an excellent and well-recognized process from the synthetic, economic, and environmental point of view. In this context, the objective of the present review is to give a global overview on the topic starting from those contributions published prior to the emergence of the BH concept to the most recent and current research under the term of BH catalysis. Two main subareas of the topic (homogeneous and heterogeneous catalysis) have been identified, from which three subheadings based on the source of the electrophile (alkanes, alcohols, and amines) have been considered. Then the type of bond being formed (carbon–carbon and carbon heteroatom) has been taken into account to end-up with the intermediate reaction working in tandem with the metal-catalyzed hydrogenation/dehydrogenation step. The review has been completed with the more recent advances in asymmetric catalysis using the BH strategy.

中文翻译：

借氢催化一锅法合成研究进展

借用氢（BH）原理（也称为氢自动转移）是一种强大的方法，它将转移加氢（避免直接使用分子氢）与一个或多个中间反应相结合，以合成更复杂的分子，而无需进行繁琐的分离或分离。隔离过程。从合成，经济和环境的角度来看，该策略通常依赖于三个步骤：（i）脱氢，（ii）中间反应和（iii）氢化，是一种出色且广为人知的方法。在这种情况下，本综述的目的是就该主题进行全球性概述，从在BH概念出现之前发表的论文到BH催化作用下的最新研究。已经确定了该主题的两个主要子区域（均相催化和非均相催化），从中考虑了基于亲电试剂来源（烷烃，醇和胺）的三个子标题。然后考虑了形成的键的类型（碳-碳和碳杂原子），以最终与金属催化的加氢/脱氢步骤协同作用的中间反应结束。使用BH策略在不对称催化方面的最新进展已经完成了该综述。然后考虑了形成的键的类型（碳-碳和碳杂原子），以最终与金属催化的加氢/脱氢步骤协同作用的中间反应结束。使用BH策略在不对称催化方面的最新进展已经完成了该综述。然后考虑了形成的键的类型（碳-碳和碳杂原子），以最终与金属催化的加氢/脱氢步骤协同作用的中间反应结束。使用BH策略在不对称催化方面的最新进展已经完成了该综述。

更新日期：2018-01-10

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