The preparation of 2,6-difluoroaniline from 1,3,5-trichlorobenzene is described. 1-Chloro-3,5-difluorobenzene prepared via KF exchange on 1,3,5-trichlorobenzene is dichlorinated and nitrated in a single reactor to a mixture of trichlorodifluoronitrobenzenes. The latter are reduced to ∼4:1 isomeric mixture of 2,6-difluoroaniline and 2,4-difluoroaniline.

中文翻译：

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芳香氟化学。第4部分。2.6-二氟苯胺的制备

描述了由1,3,5-三氯苯制备2,6-二氟苯胺。通过在1,3,5-三氯苯上的KF交换制备的1-氯-3,5-二氟苯在单个反应器中被二氯化和硝化成三氯二氟硝基苯的混合物。后者被还原为2,6-二氟苯胺和2,4-二氟苯胺的〜4：1异构体混合物。