Recent advances in the intramolecular Mannich reaction in natural products total synthesis,Organic Chemistry Frontiers

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Recent advances in the intramolecular Mannich reaction in natural products total synthesis
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7qo01079f
Yingbo Shi _{1,

2,

3,

4} , Qiaoling Wang _{4,

5,

6} , Shuanhu Gao _{1,

2,

3,

4,

7}

Affiliation

The Mannich reaction has been widely used to effectively construct C–N and C–C bonds in organic synthesis. This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017). The organization of the synthetic applications is based on the structure of newly-formed skeletons using the intramolecular Mannich reaction, which include aza-fused rings and aza-bridged rings.

中文翻译：

天然产物全合成中分子内曼尼希反应的最新进展

曼尼希反应已被广泛用于在有机合成中有效地构建C–N和C–C键。这篇综述着重介绍了分子内曼尼希反应的部分应用，将其作为天然产物全合成的关键步骤（2000-2017年）。合成应用的组织基于使用分子内曼尼希反应的新形成骨架的结构，其中包括氮杂稠合环和氮杂桥环。

更新日期：2018-01-09

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