The synthesis of novel functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl)oxy]acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo[3,2-b]pyridines.

中文翻译：

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一种功能化的3-氨基-N-甲基呋喃并[3,2 - b ]吡啶-2-羧酰胺的简便方法

从氰基吡啶中间体描述了新型功能化的3-氨基-N-甲基呋喃并[3,2 - b ]吡啶-2-羧酰胺的合成。基于卤素反应性的差异，在环化成所需的呋喃并[3,2- b ]吡啶之前，通过钯催化的反应对[（5-溴-2-氯吡啶基-3-基）氧基]乙酸乙酯进行官能化。。