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A convenient route to functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides
Tetrahedron ( IF 2.1 ) Pub Date : 2011-05-14 , DOI: 10.1016/j.tet.2011.05.035 Anne Bretéché , Pascal Marchand , Marie-Renée Nourrisson , Patrick Hautefaye , Guillaume De Nanteuil , Muriel Duflos
中文翻译:
一种功能化的3-氨基-N-甲基呋喃并[3,2 - b ]吡啶-2-羧酰胺的简便方法
更新日期:2011-05-14
Tetrahedron ( IF 2.1 ) Pub Date : 2011-05-14 , DOI: 10.1016/j.tet.2011.05.035 Anne Bretéché , Pascal Marchand , Marie-Renée Nourrisson , Patrick Hautefaye , Guillaume De Nanteuil , Muriel Duflos
The synthesis of novel functionalized 3-amino-N-methylfuro[3,2-b]pyridine-2-carboxamides is described from cyanopyridine intermediates. Based on the difference in halogen reactivity, ethyl [(5-bromo-2-chloropyridin-3-yl)oxy]acetate was functionalized by a palladium-catalyzed reaction, before the cyclization to the desired furo[3,2-b]pyridines.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
一种功能化的3-氨基-N-甲基呋喃并[3,2 - b ]吡啶-2-羧酰胺的简便方法
从氰基吡啶中间体描述了新型功能化的3-氨基-N-甲基呋喃并[3,2 - b ]吡啶-2-羧酰胺的合成。基于卤素反应性的差异,在环化成所需的呋喃并[3,2- b ]吡啶之前,通过钯催化的反应对[(5-溴-2-氯吡啶基-3-基)氧基]乙酸乙酯进行官能化。。