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Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (−)-triptolide
Tetrahedron ( IF 2.1 ) Pub Date : 2010-05-31 , DOI: 10.1016/j.tet.2010.05.035 Bing Zhou , Xiaomei Li , Huijin Feng , Yuanchao Li
中文翻译:
有效合成关键的中间体雷公藤酚甲醚用于合成(-)-雷公藤内酯
更新日期:2010-05-31
Tetrahedron ( IF 2.1 ) Pub Date : 2010-05-31 , DOI: 10.1016/j.tet.2010.05.035 Bing Zhou , Xiaomei Li , Huijin Feng , Yuanchao Li
An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (−)-triptolide 1. The route is of characteristic of low cost, high yield and easy operation. In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield.
中文翻译:
有效合成关键的中间体雷公藤酚甲醚用于合成(-)-雷公藤内酯
从九个步骤中容易获得的松香酸3高效合成了雷公藤多酚甲醚4,并已成功应用于(-)-雷公藤内酯1的合成。该路线具有成本低,产量高,易于操作的特点。此外,此路线中的每个反应均已成功扩大规模至100 g底物水平,而没有损失收率。