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2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction
Tetrahedron ( IF 2.1 ) Pub Date : 2010-02-21 , DOI: 10.1016/j.tet.2010.02.061
Seung-Hoi Kim , Reuben D. Rieke

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields.



中文翻译:

2-吡啶基和3-吡啶基溴化锌:直接制备和偶联反应

已证明使用Rieke锌分别与2-溴吡啶和3-溴吡啶直接合成2-吡啶基和3-吡啶基锌溴化物的简便合成方法。各种不同的亲电试剂已与所得的有机锌试剂偶联,以中等至良好的产率得到相应的交叉偶联产物。

更新日期:2010-02-21
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