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Pre-schisanartanins C–D and propintrilactones A–B, two classes of new nortriterpenoids from Schisandra propinqua var. propinqua
Tetrahedron ( IF 2.1 ) Pub Date : 2010-02-04 , DOI: 10.1016/j.tet.2010.02.002
Chun Lei , Wei-Lie Xiao , Sheng-Xiong Huang , Ji-Jun Chen , Jian-Xin Pu , Han-Dong Sun

Four new nortriterpenoids, pre-schisanartanins C and D (12) with pre-schisanartane backbone, and propintrilactones A and B (34) possessed wuweiziartane framework, were isolated from the acetone extract of the stems of Schisandra propinqua var. propinqua. Their structures were characterized by extensive spectroscopic analyses. Compounds 3 and 4 existed as a pair of slowly interconverting diastereomers at room temperature; their absolute configuration was established by CD methods. Compounds 14 showed no cytotoxicity against K562, A549, and HT–29 human cancer cells.



中文翻译:

五味子前素C–D和丙三酸内酯A–B,是五味子五味子中的两类新的降冰片萜类。Propinqua

四个新nortriterpenoids,预schisanartanins C和d(1 - 2)具有预schisanartane骨干,propintrilactones A和B(3 - 4)具有wuweiziartane框架,从丙酮提取物中分离得到的茎五味子园竹变种。propinqua。通过广泛的光谱分析对它们的结构进行了表征。化合物34在室温下以一对缓慢互变的非对映异构体形式存在;它们的绝对配置是通过CD方法建立的。化合物1 - 4显示对K562,A549无细胞毒性,和HT-29人癌细胞。

更新日期:2010-02-04
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