自组装的Phe-Phe模体中的新原型诱导了核苷共轭二苯丙氨酸的纳米结构<a href="#fn1" title="提供电子补充信息（ESI）。参见DOI：10.1039 / c7nr08436f">†</a>,Nanoscale

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自组装的Phe-Phe模体中的新原型诱导了核苷共轭二苯丙氨酸的纳米结构 †
Nanoscale ( IF 5.8 ) Pub Date : 2018-01-03 00:00:00 , DOI: 10.1039/c7nr08436f
Dhrubajyoti Datta _{1,

2,

3,

4,

5} , Omshanker Tiwari _{1,

2,

3,

4,

5} , Krishna N. Ganesh _{1,

2,

3,

4,

5}

Affiliation

在过去的二十年中，短肽二苯丙氨酸（Phe-Phe）基序的分子自组装由于其独特的形态结构和在生物材料化学，传感器和生物电子学中的潜在应用而受到人们的关注。由于易于合成修饰和大量可用的实验工具，游离和受保护的二苯丙氨酸支架（H-Phe-Phe-OH，Boc-Phe-Phe-OH和Boc-Phe-Phe-OMe的自组装））呈现出有趣的管状，水泡或原纤维形态。在这个主题的基础上，我们尝试检验结构和性质（疏水和氢键）对Boc-Phe-Phe的自组装过程中功能性C末端共轭取代基的影响。由于H键导致的自排序，通过他们的SEM，HRTEM，AFM图片和DLS实验。报告了这些囊泡对不同外部刺激的稳定性，例如pH和温度，荧光探针在囊泡内部的封装以及它们通过外部触发释放的情况。研究结果为Phe-Phe母题的研究和应用提供了新的方向，以合理地设计出新的功能纳米结构。

"点击查看英文标题和摘要"

New archetypes in self-assembled Phe-Phe motif induced nanostructures from nucleoside conjugated-diphenylalanines†

During the last two decades, the molecular self-assembly of the short peptide diphenylalanine (Phe-Phe) motif has attracted increasing focus due to its unique morphological structure and utility for potential applications in biomaterial chemistry, sensors and bioelectronics. Due to the ease of their synthetic modifications and a plethora of available experimental tools, the self-assembly of free and protected diphenylalanine scaffolds (H-Phe-Phe-OH, Boc-Phe-Phe-OH and Boc-Phe-Phe-OMe) has unfurled interesting tubular, vesicular or fibrillar morphologies. Developing on this theme, here we attempt to examine the effect of structure and properties (hydrophobic and H-bonding) modifying the functional C-terminus conjugated substituents on Boc-Phe-Phe on its self-assembly process. The consequent self-sorting due to H-bonding, van der Waals force and π–π interactions, generates monodisperse nano-vesicles from these peptides characterized via their SEM, HRTEM, AFM pictures and DLS experiments. The stability of these vesicles to different external stimuli such as pH and temperature, encapsulation of fluorescent probes inside the vesicles and their release by external trigger are reported. The results point to a new direction in the study and applications of the Phe-Phe motif to rationally engineer new functional nano-architectures.

更新日期：2018-01-03

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