Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies,Chemical Reviews

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Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1021/acs.chemrev.6b00750
Hong Jiang ₁ , Xiaoyu Zhang ₁ , Xiao Chen ₁ , Pornpun Aramsangtienchai ₁ , Zhen Tong ₁ , Hening Lin ₁

Affiliation

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic cells and regulates numerous biological pathways, such as membrane trafficking, protein secretion, signal transduction, and apoptosis. We provide a comprehensive review of protein lipidation, including descriptions of proteins known to be modified and the functions of the modifications, the enzymes that control them, and the tools and technologies developed to study them. We also highlight key questions about protein lipidation that remain to be answered, the challenges associated with answering such questions, and possible solutions to overcome these challenges.

中文翻译：

蛋白质脂化：发生，机制，生物学功能和使能技术。

真核细胞中的许多蛋白质中都发生蛋白质脂化，包括半胱氨酸异戊二烯化，N末端甘氨酸肉豆蔻酰化，半胱氨酸棕榈酰化以及丝氨酸和赖氨酸脂肪酰化，并调节了许多生物途径，例如膜运输，蛋白质分泌，信号转导和凋亡。我们提供了蛋白质脂化的全面综述，包括对已知要修饰的蛋白质的描述以及修饰的功能，控制它们的酶以及研究它们的工具和技术。我们还将重点介绍仍需解决的有关蛋白质脂化的关键问题，与回答此类问题相关的挑战，以及克服这些挑战的可能解决方案。

更新日期：2018-01-02

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