Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, the NMR sensitivity of the nuclei in molecules can be dramatically enhanced. Recent application of the hyperpolarization technique has led to advances in biochemical and molecular studies. A major problem is the short lifetime of the polarized nuclear spin state. Generally, in solution, the polarized nuclear spin state decays to a thermal spin equilibrium, resulting in loss of the enhanced NMR signal. This decay is correlated directly with the spin‐lattice relaxation time T₁. Here we report [¹³C,D₁₄]tert‐butylbenzene as a new scaffold structure for designing hyperpolarized ¹³C probes. Thanks to the minimized spin‐lattice relaxation (T₁) pathways, its water‐soluble derivative showed a remarkably long ¹³C T₁ value and long retention of the hyperpolarized spin state.

中文翻译：

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合理设计[13C,D14]叔丁基苯作为支架结构，用于设计长寿命超极化 13C 探针

动态核极化（DNP）是一种使核自旋群体极化的技术。由于超极化，分子中原子核的核磁共振灵敏度可以显着增强。超极化技术的最新应用促进了生化和分子研究的进步。一个主要问题是极化核自旋态的寿命短。通常，在溶液中，极化核自旋态衰减至热自旋平衡，导致增强的 NMR 信号丢失。这种衰减与自旋晶格弛豫时间T ₁直接相关。在这里，我们报告[ ¹³ C,D ₁₄ ]叔丁基苯作为设计超极化¹³ C 探针的新支架结构。由于自旋晶格弛豫 ( T ₁ ) 途径最小化，其水溶性衍生物表现出非常长的¹³ C T ₁值和超极化自旋态的长期保留。