A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl group, is described here. This new modified nucleotide is expected to generate RNA analogues potentially useful in applications where proper RNA folding is required since the 2′-hydroxyl is conserved.

中文翻译：

---

2'- C-甲基尿苷亚磷酰胺：制备带有2'-羟基的RNA类似物的新构件

进行了2'- C-甲基尿苷的新的立体选择性合成。这里描述了适合于寡核苷酸的自动合成的相应的受保护的亚磷酰胺的制备，包括2'-羟基的区域选择性保护。由于保守的2'-羟基，预计这种新的修饰核苷酸会产生RNA类似物，在可能需要正确折叠RNA的应用中潜在地有用。