Radical Cyclization of Epoxy Vinyl- and Allylsulfones Promoted by Titanocene Chloride,The Journal of Organic Chemistry

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Radical Cyclization of Epoxy Vinyl- and Allylsulfones Promoted by Titanocene Chloride
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2015-04-15 00:00:00 , DOI: 10.1021/acs.joc.5b00206
A. Fernández-Mateos ₁ , S. Encinas Madrazo ₁ , P. Herrero Teijón ₁ , R. Rubio González ₁

Affiliation

A titanocene-mediated intramolecular radical addition of different epoxy vinyl- and allylsulfones has been achieved. Five- and six-membered ring products were obtained in good to excellent yields in the presence of both 2.2 and 0.2 equiv of Cp₂TiCl. A novel double-activation strategy allowed us to achieve small-size rings such as cyclobutanes and cyclopropanes.

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