Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal–Bisphosphonate Coordination Chemistry for Wound Healing,Advanced Healthcare Materials

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Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal–Bisphosphonate Coordination Chemistry for Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-27 , DOI: 10.1002/adhm.201700973
Liyang Shi ₁ , Yannan Zhao ₂ , Qifan Xie ₃ , Caixia Fan ₂ , Jöns Hilborn ₁ , Jianwu Dai ₂ , Dmitri. A. Ossipov ₁

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Biomaterial‐based regenerative approaches would allow for cost‐effective off‐the‐shelf solution for the treatment of wounds. Hyaluronan (HA)‐based hydrogel is one attractive biomaterial candidate because it is involved in natural healing processes, including inflammation, granulation, and reepithelialization. Herein, dynamic metal–ligand coordination bonds are used to fabricate moldable supramolecular HA hydrogels with self‐healing properties. To achieve reversible crosslinking of HA chains, the biopolymer is modified with pendant bisphosphonate (BP) ligands using carbodiimide coupling and chemoselective “click” reactions. Hydrogel is formed immediately after simple addition of silver (Ag⁺) ions to the solution of HA containing BP groups (HA‐BP). Compared with previous HA‐based wound healing hydrogels, the HA‐BP·Ag⁺ hydrogel is highly suitable for clinical use as it can fill irregularly shaped wound defects without the need for premolding. The HA‐BP·Ag⁺ hydrogel shows antimicrobial properties to both Gram‐positive and Gram‐negative bacterial strains, enabling prevention of infections in wound care. In vivo evaluation using a rat full‐thickness skin wound model shows significantly lower wound remaining rate and a thicker layer of regenerated epidermis as compared with the group left without treatment. The presented moldable and self‐healing supramolecular HA hydrogel with “ready‐to‐use” properties possesses a great potential for regenerative wound treatment.

中文翻译：

动态金属-双膦酸酯配位化学实现的可塑透明质酸水凝胶用于伤口愈合

基于生物材料的再生方法将为治疗伤口提供经济有效的现成解决方案。基于透明质酸（HA）的水凝胶是一种有吸引力的生物材料候选物，因为它参与了自然愈合过程，包括炎症，肉芽形成和再上皮形成。本文中，动态金属-配体配位键用于制备具有自愈特性的可模塑超分子HA水凝胶。为了实现HA链的可逆交联，使用碳二亚胺偶联和化学选择性“点击”反应，用双膦酸酯侧基（BP）配体修饰生物聚合物。简单添加银（Ag ⁺）离子到含有BP基团（HA‐BP）的HA溶液中。与以前的基于HA的伤口愈合水凝胶相比，HA-BP·Ag ⁺水凝胶非常适合临床使用，因为它可以填充不规则形状的伤口缺损而无需预先成型。HA-BP·Ag ⁺水凝胶对革兰氏阳性和革兰氏阴性细菌均显示出抗菌性能，从而可以防止伤口护理中的感染。与未经治疗的组相比，使用大鼠全厚度皮肤伤口模型进行的体内评估显示，伤口保留率显着降低，而再生表皮层更厚。呈现的具有“即用型”特性的可塑型，可自我修复的超分子HA水凝胶具有再生伤口治疗的巨大潜力。

更新日期：2017-12-27

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