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One-pot synthesis of symmetrical P1,P2-dinucleoside-5′-diphosphates from nucleoside-5′-H-phosphonates: mechanistic insights into reaction path
Tetrahedron Letters ( IF 1.5 ) Pub Date : 17 July 2013 , DOI: 10.1016/j.tetlet.2013.05.040 Qi Sun , Si Liu , Jian Sun , Shanshan Gong , Qiang Xiao , Liang Shen
Tetrahedron Letters ( IF 1.5 ) Pub Date : 17 July 2013 , DOI: 10.1016/j.tetlet.2013.05.040 Qi Sun , Si Liu , Jian Sun , Shanshan Gong , Qiang Xiao , Liang Shen
Six symmetrical P1,P2-dinucleoside-5′-diphosphates (Np2Ns) have been synthesized from nucleoside-5′-H-phosphonate monoesters via a one-pot reaction in high yields. The key sequential hydrolysis protocol was developed based on the observation of reactive P1,P2,P3-trinucleoside-5′-triphosphate intermediate on 31P NMR.
中文翻译：
从核苷5'- H-膦酸酯一锅法合成对称的P 1，P 2-二核苷5'-二磷酸酯：对反应路径的机理认识
已经通过一锅反应从核苷-5'- H-膦酸酯单酯合成了六种对称的P 1，P 2-二核苷-5'-二磷酸酯（Np 2 Ns），产率很高。基于在31 P NMR上观察到反应性P 1，P 2，P 3-三核苷-5'-三磷酸酯中间体，开发了关键的顺序水解方案。
更新日期：2017-01-31
中文翻译：
从核苷5'- H-膦酸酯一锅法合成对称的P 1，P 2-二核苷5'-二磷酸酯：对反应路径的机理认识
已经通过一锅反应从核苷-5'- H-膦酸酯单酯合成了六种对称的P 1，P 2-二核苷-5'-二磷酸酯（Np 2 Ns），产率很高。基于在31 P NMR上观察到反应性P 1，P 2，P 3-三核苷-5'-三磷酸酯中间体，开发了关键的顺序水解方案。
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